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Do a college thesis on the CIC1402 scientific trial heart

CIC thesis

The Clinical Investigation Center (CIC 1402) of the University Hospital of Poitiers welcomes new PhD students every year who come to write their university thesis. Born of a partnership between the CHU of Poitiers, Inserm and the University of Poitiers, the CIC1402 forms the interface between the clinicians of the CHU and the basic research teams, making it an ideal training ground.

A multi-thematic structure, at the interface between basic research and clinical practice

The clinical test center fulfills both a teaching and a research assignment. “That’s what we call training by and on the lookout”, explains Elodie Migault, Executive Director of the CIC. In fact, the CIC welcomes many students from the health and science sectors.

In the period 2016-2021, 18 university theses were supervised by CIC researchers, most of them within the framework of the Rosalind Franklin Doctoral School. Certain collaborations with research teams at the university or the CNRS also allow certain co-supervisions.

The research topics of CIC1402 are organized around four main axes in clinical investigation, one in biostatistics and three in technological innovation. “The fact that the CIC is multi-thematic is a real strength for sharing and cross-functional projects,” emphasizes Elodie Migault.

Who are the CIC doctoral students?

Here are two examples of thesis work carried out at the CIC: Guillaume Binson from the Department of Clinical Pharmacy studied the effects of exposure of preterm infants to the parabens contained in medicines during his PhD; Evelyne Liuu from the Geriatrics Department looked for the link between vascular complications and cancer risk in patients with diabetes.

“The CIC also welcomes PhD students from science fields, for which we have previously responded to a call for projects with a view to funding a PhD student”, says Professor Pierre-Jean Saulnier, coordinating doctor of the CIC. For example, Inès Castilla is currently doing her doctorate in the Xlim laboratory at Pr Philippe Carré, in co-supervision with the CIC, on the development of an algorithm that uses smartphone data to detect Alzheimer’s disease.

Doing your thesis at the CIC gives you access to its facilities – the Center for Biological Resources (BRC), the Biostatistical Methods Platform, the Neurorespiratory Physiology Platform and the Hypoxia Chamber. The CIC also provides doctoral students with their own office, especially for clinicians, so that they can detach themselves from their clinical work and concentrate on their research work.

A doctoral committee is organized annually with each doctoral candidate in the form of individual discussions. This time allows for discussions with the PhD student but also with the tutor(s) to measure progress and identify possible collaborations within the CIC teams themselves. The development of the original scientific question is also discussed with regard to the first results. This also represents a training presentation for the doctoral student about the progress of his work.

Testimonial: Corentin Faucher, doctoral student in sports science

Corentin Faucher’s dissertation focuses on the interactions of cold – cryostimulation – and oxygen deprivation – hypoxia – on the body in the context of physical preparation of athletes. The goal here is to examine the cross-fits of these two parameters. “In extreme sports such as mountaineering, we encounter these two conditions at the same time: extreme cold and lack of oxygen at high altitude”. The results of this research will allow these athletes to better prepare their bodies by understanding how these diseases affect their metabolism.

Corentin Faucher’s dissertation involves healthy male subjects aged 18 to 30 years with a high level of physical activity. It assesses the person’s response to hypoxia and cryostimulation at rest and during activity, and specifically the effects on the autonomic nervous system, which can affect heart rate, respiratory rate and metabolism. In fact, in extreme situations such as hypoxia or very low temperatures, the body is exposed to stress and develops responses to this stress. This is exactly what is measured in this research. The results will then be used primarily for the preparation of top athletes, especially with a view to the 2024 Olympic Games, but also for the management of certain metabolic diseases.

Corentin Faucher is doing his PhD both at the CIC1402, which has a hypoxia chamber, equipment that is unique in France in a university hospital, and at the MOVE research laboratory (UR 20296) at the University of Poitiers, which has cryostimulation equipment. “My thesis brings together the expertise of these labs and my directors to provide new data and insights on the subject,” says Corentin Faucher.

The students who applied for this thesis subject were auditioned. Corentin Faucher was finally chosen for this work. He is beginning his second PhD year, which is expected to last three years, just in time for athletes to use the data and results for the 2024 Olympics.

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